A bacterial toxin and a nonenveloped virus hijack ER-to-cytosol membrane translocation pathways to cause disease
نویسندگان
چکیده
منابع مشابه
Structural peptides of a nonenveloped virus are involved in assembly and membrane translocation.
The capsid of infectious bursal disease virus (IBDV), a nonenveloped virus of the family Birnaviridae, has a T=13l icosahedral shell constituted by a single protein, VP2, and several disordered peptides, all derived from the precursor pVP2. In this study, we show that two of the peptides, pep11 and pep46, control virus assembly and cell entry. Deletion of pep11 or even simple substitution of mo...
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Toxin Instability and Its Role in Toxin Translocation from the Endoplasmic Reticulum to the Cytosol
AB toxins enter a host cell by receptor-mediated endocytosis. The catalytic A chain then crosses the endosome or endoplasmic reticulum (ER) membrane to reach its cytosolic target. Dissociation of the A chain from the cell-binding B chain occurs before or during translocation to the cytosol, and only the A chain enters the cytosol. In some cases, AB subunit dissociation is facilitated by the uni...
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ژورنال
عنوان ژورنال: Critical Reviews in Biochemistry and Molecular Biology
سال: 2015
ISSN: 1040-9238,1549-7798
DOI: 10.3109/10409238.2015.1085826